Dr. Ji-Sheng Han

Dr Ji-Sheng Han
Dr. Ji-Sheng Han
Chairman of the Board of Directors, Director of Research

Dr. Ji-Sheng Han is the Director of the Neuroscience Research Institute at Beijing University. He is also an Adviser of the World Health Organization and National Institute of Health. He is the inventor of the “Han’s acupoint nerve stimulator” (HANS) used to treat neurological disorders and pain. He has been the recipient of numerous awards for his outstanding work of 50 years.

Education

1947-52 Shanghai Medical College, graduate in medicine, Shanghai, China
1952-53 Dalian Medical College, majoring in Physiology, Dalian, China

Academic Appointments

1953-56 Assistant, Dept. of Physiology, Harbin Medical University, Harbin, China
1956-79 Lecturer in Physiol, Institute for Advanced Training of Medical Personnel, Peking (56-61);
Beijing Chinese Traditional Medical College (61-62);
Beijing Medical College, Beijing (62-79)
1979-99 Professor, Dept. of Physiology, Beijing Medical University (BMU), Beijing
1983-93 Chairman, Department of Physiology, BMU
1993- Member (Academician), Chinese Academy of Sciences
1994- Director, Key Laboratory of Neuroscience Res, Ministry of Public Health, P.R.China
2000- Professor and Director, Neuroscience Research Institute, Peking University, Beijing
2001- Director, Key Laboratory of Neuroscience Res, Ministry of Education, PR China
Director, Department of Neurobiology, Peking University

Other Responsibilities

Board of Basic Med Sci, National Committee for Academic Degrees, PRC (1985-)
Chairman, Board of Medical Sciences, Foundation of Post-doctoral Fellowship, PRC (1990-)
President, Chinese Association for the Study of Pain (CASP, China Chapter of IASP), (1989-)
Vice president, Chinese Physiological Society (1994-1998)
Vice president, Chinese Society for Neuroscience (1994-99), Liaison for IBRO (1994-)
Scientific Advisor, World Health Organization (WHO), (1990-)
Consultant, Scientific Review Committee, NIH and ADAMHA, USA (1991-)
Executive Committee, International Narcotic Research conference (INRC), (2002-2006)

Editorial Experience

Editor-in-chief, PROGRESS IN PHYSIOLOGICAL SCIENCES, Beijing (1986-2000)
Honorary Editor-in-Chief, PROGRESS IN PHYSIOLOGICAL SCIENCES, Beijing (2001-)
Editor-in-chief, CHINESE JOURNAL of PAIN MEDICINE, Beijing (1995-)
Executive Editor CHINESE PHARMACOLOGICAL BULLETIN, Hefe (1985-)
Advisory Board, INTERNATIONAL J. NEUROSCIENCE, New York (1982-)

Research Interest

Neurochemical basis of acupuncture-induced analgesia;
Narcotic addicts treated with Han’s acupoint nerve stimulation (HANS);
Molecular biology of neurotransmitters and neuropeptides in CNS;
Basic research for the gene therapy of Parkinson’s Disease.

Supervisor for Ph.D. Students

56 Ph.D. graduated since 1984, more than 80 fellows and postdoctorals since 1973.

Publications

Professor Han has published over 400 papers and 7 books, including:

Essentials of Neuroscience, 962pp, 1993; (In Chinese),
Principles of Neuroscience, 1171pp, 1999 (In Chinese);
The Neurochemical Basis of Pain Relief by Acupuncture, vol. 1, 597pp, 1987 (In English);
The Neurochemical Basis of Pain Relief by Acupuncture, vol.2, 783pp, 1998 (In English);
Mechanisms of acupuncture analgesia, 255 pp, 1999 (In Chinese)

Invited Overseas Lectures and Presentations

Delivering lectures in more than 100 Universities or Institutions in 26 countries and areas since 1979, including: UCSF, Stanford, Washington U, Duke U, NYU, Rockefeller, Harvard, NIH, NIMH, U Toronto, Karolinska Inst, U London, Max-Planck Munich, Heidelberg, U Milan, etc.

Plenary speaker, 12th International Congress of Pharmacology, Montreal, 1994; The first Joint meeting of US-China Academy of Sciences, After-Dinner Speech, 1997; Chairman and speaker of the session “Acupuncture” in the IBRO world Congress of Neuroscience held in Jerusalem, 1999, etc.

GRANTS: Supported by the National Institute of Drug Abuse (NIDA), NIH, USA for the study of Neurobiology of Acupuncture Analgesia for 13 consecutive years, and by the National Natural Science Foundation and the Ministry of Science and Technology of China, etc.. A recent grant from the NIH is a central grant applied jointly with the Harvard Medical School on the research using acupuncture for the treatment of cocaine addiction (2005-2009).

Reviews

Han JS, Terenius L. Neurochemical basis of acupuncture analgesia. Ann Rev Pharmacol Toxicol 1982; 22:193-220
Han JS. Central Neurotransmitters and Acupuncture Analgesia. In: B Pomeranz, G Stux (Editors), Scientific Bases of Acupuncture, Springer-Verlag, Berlin, Heidelberg, New York, London, Paris and Tokyo., 1988, pp 7-34
Han JS, Wang J. Mobilization of specific neuropeptides by peripheral stimulation of identified frequencies. News Physiological Sciences (USA) 1992; 7:176-180
Han JS. The role of CCK in acupuncture analgesia and acupuncture tolerance. In: Multiple CCK Receptors in the CNS (Eds: Dourish, Cooper, Iversen, Iversen) Oxford, New York, 1992, pp480-502
Han JS. Acupuncture and stimulation-induced analgesia. In: Handbook of Experimental Pharmacology, vol 104. OPIODS (Ed. A Herz) Chapter 35, Springer, 1993, pp105-125
Han JS. Molecular events underlying the anti-opioid effect of CCK-8 in the CNS. In: Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s. (Eds: Cuello, Collier) Birckhauser, Basel, 1995; pp 199-207
Han JS. Acupuncture activates endogenous system of analgesia. In: NIH consensus Development Conference on Acupuncture, Nov 3-5, 1997, pp 55-60
Han JS. Physiology of acupuncture: Review of thirty years of research. J Altern Complem Med 1997; 3 (Suppl): 101-108
Ulett G, Han S, Han JS. Electroacupuncture: mechanisms and clinical application. Biol Psychiatry. 1998 Jul 15;44(2):129-38. Review.
Han JS. Mechanisms of Acupuncture Analgesia. Shanghai Press of Science and Technology, Shanghai China, 1999, pp 1-255 (in Chinese)
Han JS. Opioid and anti-opioid peptides: A model of Yin-Yang balance in acupuncture mechanisms of pain modulation. In: G. Stux, R Hammerschlag (Editors), Clinical Acupuncture, Scientific Basis, Springer: Berlin and Heidelberg 2001, pp51-68
Han JS. Acupuncture: Frequency dependent release of neurpeptides in CNS. Trends in Neuroscience, 2003, 26: 17-22
Han JS. Acupuncture, Chapter 49 of the , A Comprehensive Textbook, Eds. J Lowinson et al. 4th edition, 2005, Lippincott Williams & Wilkins, Philadelphia, pp.743-762

Selected Articles

Research Group of Acupuncture anesthesia, Beijing Medical college: The role of some neurotransmitters of brain in acupuncture analgesia. Scientia Sinica 1974; 17:112-130
Han JS, et al. The role of central catecholamine in acupuncture analgesia. Chin Med J. 1979; 92(11):793-800
Zhou ZF et al. Effect of intracerebral microinjection of naloxone on acupuncture- and morphine-analgesia in the rabbit. Scientia Sinica. 1981; 24(8):1166-78.
Han JS, et al. Tolerance to acupuncture and its cross tolerance to morphine. Neuropharmacology 1981; 20:593-596
Han JS, et al. Acupuncture has an analgesia effect in rabbits. Pain 1983; 15:83-91
Han JS, et al. Dynorphin: Important mediator for electroacupuncture analgesia in the spinal cord of the rabbit. Pain 1984; 18:367-376
Han JS, et al. Acupuncure mechanisms in rabbits studied with microinjection of antibodies against beta-endorphin, enkephalin and substance P. Neuropharmacology 1984; 23:1-5
Han JS. Met-enkephalin-Arg6-Phe7-like immunoreactive substances mediate electroacupuncture analgesia in the periaqueductal gray of the rabbit. Brain Res. 1984 Nov 26;322(2):289-96.
Han JS. Is cholecystokinin octapeptide (CCK-8) a candidate for endogenous anti-opioid substrates? Neuropeptides. 1985 Feb;5(4-6):399-402.
Han JS. Cholecystokinin octapeptide (CCK-8): antagonism to electroacupuncture analgesia and a possible role in electroacupuncture tolerance. Pain. 1986 Oct;27(1):101-15.
Xuan YT, et al. Studies on the mesolimbic loop of antinociception-II. A serotonin-enkephalin interaction in the nucleus accumbens. Neuroscience 1986; 19:403-409
Han JS. A mesolimbic neuronal loop of analgesia. Adv Pain Res Ther 1987; 10:219-243
Li Y, Han JS. CCK-8 antagonizes morphine analgesia in periaqueductal gray of the rat. Brain Res 1989; 480:105-110
Wang Q, et al. Characterization of inhibition of spinal nociceptive reflex by stimulation of the arcuate nucleus of the hypothalamus in the pentobarbital anesthetized rat. Pain 1990:41:101-108
Wang Q, et al. Diencephalon as a cardinal neural structure for mediating 1 Hz- but not 100 Hz- electroacupuncture-induced tail flick reflex suppression. Beh Brain Res 1990; 37:149-156
Wan Q, et al. Analgesic electrical stimulation of the hypothalamic arcuate nucleus: tolerance and its cross-tolerance to 2 Hz or 100 Hz electroacupuncture. Brain Res. 1990 Jun 4;518(1-2):40-6.
Wang Q et al. Lumbar intrathecal administration of naloxone antagonizes analgesia produced by electrical stimulation of the hypothalamic arcuate nucleus in pentobarbital anesthetized rats. Neuropharmacology 1990; 29:1123-1129
Wang XJ, Han JS. Modification by CCK-8 of the binding of mu, delta and kappa opioid receptors. J Neurochem 1990; 55:1379-1382
Wang XJ, Han JS. CCK-8 antagonized opioid analgesia mediated by mu and kappa but not delta receptors in the spinal cord of the rat. Brain Res 1990; 523:5-10
Han JS, et al. Effect of low- and high-frequency TENS on met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human CSF. Pain 1991; 47:295-298
Han JS, Ren MF. The importance of monitoring tail skin temperature in measuring tail flick latency. Pain 1991; 46:117
Ma QP, Han jS. Neurochemical studies on the mesolimbic circuitry of antinociception. Brain Res 1991; 566:95-102
Chen XH, Han JS. All three types of opioid receptors in the spinal cord are important for 2/15 Hz electroacupuncture analgesia. Eur J Pharmacol. 1992 Feb 11;211(2):203-10.
Chen XH, Han JS. All three types of opioid receptors are important for 2/15 Hz electroaupuncture analgesia. Eur J Pharmacol 1992; 211:203-210
Chen XH, Han JS. Analgesia induced by electroacupuncture of different frequencies is mediated by different types of opioid receptors: anlther cross tolerance study. Beh Brain Res 1992; 47:143-149
Zhang LJ et al. Influence of CCK-8 on phsphoinositide turnover in neonatal rat brain cells. Biochem J 1992; 285:487-850
Wang JF, et al. Mobilization of calcium from intracellular stores as one of the mechanisms underlying the antiopioid effect of CCK-8. Peptides 1992; 13:947-951
Zhou Y, et al. Increaed release of immunoreactive CCK-8 by morphine and potentiation of opioid analgesia by CCK-B receptor antagonist L-365260 in rat spinal cord. Eur J Pharmacol 1993; 234:147-154
Han JS, Zhang RL. Suppression of morphine abstinence syndrome by body electroacupuncture of differene frequencies in rats. Drug Alcohol Dependence 1993; 31:169-175
Han JS, et al: Heroin addicts treated with transcutaneous electric nerve stimulation of identified frequencies. Regulatory Peptides 1994; 54:115-116
Xu W, et al. Spinal serotonin 1A and 1C/2 receptors mediate supraspinal mu-opioid-induced analgesia. NeuroReport 1994; 5:2665-2668
Xu W, et al. Serotonin receptor subtypes in spinal antinociception in the rat. J Pharmacol Exp Ther 1994; 269:1182-1189
Zhang LJ, et al. Regulation by lithium of the antagonistic effect of CCK-8 on ohmefentanyl-induced antinociception.. Neurophamacology 1994; 33:123-126
Liu NJ, et al. CCK-8 reverses mu-opiod receptor-mediated inhibition of calcium current in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 1995; 275:1293-1299
Guo HF, et al. Brain substrates activated by electroacupuncture of different frequencies (I) Comparative study on the expression of oncogene c-fos and genes coding for the three opioid peptides. Mol Brain Res 1996; 43:157-166
Guo HF, et al. Brain substrates activated by electroacupuncture of different frequencies (II) Role of Fos/Jun proteins in the EA-induced transcription of preproenkephalin and preprodynorphin genes. Mol Brain Res 1996; 43:167-173
Xu T, et al. CCK-8 reverses the kappa-opioid receptor mediated depression of calcium current in rat dorsal root ganglion neurons. Brain Res 1996; 730:207-211
Han JS. Cholecystkinin (CCK): Negative feedback control for opioid analgesia. Beh Brain Science 1997; 20:451
Tang NM, et al. CCK antisense RNA increases the analgesic effect induced by electroaupuncture or low dose morphine: Conversion of low responder rats into high responders. Pain 1997; 71:71-80
Tian JH, et al. Birectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. Br J Pharmacol 1997: 120:676-680
Tian JH, et al. Involvement of endogenous Orphanin FQ in electroacupuncture induced analgesia. Neuroreport 1997; 8:497-500
Zhang LX, et al. Rats with decreased brain CCK levels show increased responsiveness to peripheral electrical stimulation-induced analgesia. Brain Res 1997; 745:158-164
Zhang M, et al. OFQ reverses the kappa opioid receptor-mediated depression of calcium current in rat dorsal root ganglion neurons. Neuroreport 1998; 9:2095-2098
Tian JH, et al. Endogenous orphanin FQ: evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture. Brit J Pharmacol 1998; 124:21-26
Han Z, et al: Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat. Neurosc Lett 1999; 274:75-78
Wang XM, et al. Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA level in the rat brain. Mol Brain Res 1999; 66:164-167
Wu LZ, et al. Suppression of morphine withdrawal by electroacupuncture in rats: dynorphin and kappa-opioid receptor implicated. Brain Res 1999, 851:290-296
Yuan L, et al. Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats. Brain Res 1999; 826:330-334
Zhao CS, et al. Nocistatin reverses the effect of orphanin FQ/nociceptin in antagonizing morphine analgesia. Neuroreport 1999; 10:297-299
Cui CL, et al.. Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal in the rat. Neurosc Lett 2000, 295:45-48
Fang M, et al. Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat. Neuroreport 2000; 11:737-741
Han NL, et al.. Synergistic effect of CCK and angiotensin II in reversal of morphine induced analgesia in rats. Pain 2000; 85:465-469
Huang C, et al. Endomorphin and mu-opioid receptors in mouse brain mediate the analgesic effect induced by 2 Hz, but not 100 Hz EA stimulation. Neurosc Lett 2000; 294:159-162
Ma DD, et al. NIH 3T3 cells or engineered NIH 3T3 cells stably expressing GDNF can protect primary dopaminergic neurons. Neurol Res 2000, 22:538-544
Tian JH, Han JS. Functional studies using antibodies against OFQ/nociceptin. Peptides 2000, 21:1047-50
Wang B, et al. Peripheral electric stimulation inhibit morphine-induced place preference in rats. Neuroreport 2000; 11:1017-1020
Wang B,et al. Stress or drug priming induces reinstatement of extinguished conditioned place preference. NeuroReport 2000, 11:2781-84
Wang Y, et al. Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat. Life Sci 2000; 67:261-267
Chen ZW, et al. The metabolic evidence of synergistic effect between ohmefentanym and [D-Pen2, D-Pen5]enkephalin on differentiated SH-SY5Y cells in humans. Neuroscience Lett 2001; 298:199-202
Chen ZW, et al. The metabolic evidence of synergistic interaction bwteeen DAMGO and DPDPE on undifferentiated SH-SY5Y cells. NeuroReport 2001;12:845-849
Sun RQ, et al. Changes in brain content of nociceptin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain. Neurosci Lett, 2001; 311:13-16
Sun RQ, Zhao CS, Wang HJ, Jing Z, Wang W, Yang K, Wang Y, Chang JK, Han JS. Nocistatin, a peptide that reverses acute and chronic morphine tolerance. NeuroReport, 2001, 12: 1789-1792
Wang Y, Wang XM, Han JS. Discrimination between peptide and non-peptide agonists on the transcription of opioid receptors in two cell lines. Life Science 2001; 68:2731-2740
Wan Y, Wilson SG, Han JS. The effect of genotype on sensitivity to electroacupuncture analgesia. Pain 2001; 91:5-13
Ren YH, Wang B, Luo F, Cui CL, Zheng JW, Han JS. Peripheral electric stimulation attenuates the expression of cocaine-induced place preference in rats. Brain Research.2002; 957: 129-135.
Wang B, Luo F, Ge XC, Fu AH, Han JS. Effects of lesions of various brain areas on drug priming or footshock-induced reactivation of extinguished conditioned place preference. Brain Research 2002; 950:1-959.
Fang M, Wang Y, He QH, Sun YX, Deng LB, Wang XM, Han JS. Glia cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalfesia in adjuvant rat pain model. Neuroscience, 2003;117: 503-512
Shi XD, Ren XW, Wang GB, Luo F, Han JS, Cui CL. Brain opioid-recpetors are involved in medtating peripheral electeic stimulation –induced inhibition of morphine conditioned place preference in rats. Brain Research 2003; 981:23-29
Zhang WT, Jin Z, Cui GH, Zhang KL, Zhang L, Zeng YW, Luo F, Chen CAN, Han JS. Relations betweenbrain network activation and analgesic effect induced by low versus high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imaging study. Brain Res 2003; 982:168-178
Zhang WT, Jin Z, Huang J, Zhang L, Zeng YW, Luo F, Chen CAN, Han JS. Modulation of cold pain in human brain by electric acupoint stimulation: evidence from fMRI. Neuroreport 2003; 14:1591-96
Han JS. Acupuncture and endorphins. Neurosc Lett 2004; 361:258-261
Zhang M, Wang XM, Zhang DB, Xu GH, Dog HW, Yu YX, Han JS. Orphanin FQantagonizes the inhibition of Ca2+ currents induced by u-opioid erceptors. J Mol Neurosc 2004; 25: in press
Shi XD, Wang GB, Ma YY, Ren W, Luo F, Cui CL, Han JS. Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP n rats: accelerated expression of PPE and PPD mRNA in NAc implicated. Mol Brain Res 2004; 130:124-133

Curriculum Vitae

Prof. Han was born in 1928 in Hangzhou, a beautiful city in south China. He finished his medical training in Shanghai Medical College (1947-1952), and specialized as a physiologist in Dalian Medical College. He started his teaching and research career on medical physiology in Harbin Medical University (1953), and was appointed as a lecturer of physiology in the Beijing college of Traditional Chinese Medicine (1961). He joined Beijing Medical University in 1962, and was appointed as a full professor of physiology (1979-), Director of the Department of Physiology (1983-1993), then Director of Neuroscience Research Institute, and Director of the Key Laboratory of Neuroscience Research under the auspice of the Ministry of Health and the Ministry of Education, People’s Republic of China (1993-). In the same year of 1993, Professor Han was elected a member of the Chinese Academy of Sciences, the highest honor for scientists in China.

Research Field

Professor Han has been engaged in the research of basic mechanisms of acupuncture therapy since 1965, a research project assigned by late Zhou En-Lai, the premier of the People’s Republic of China. After a thorough investigation of the phenomena of acupuncture-induced analgesia in humans and in animal models, he started to study its neurochemical mechanisms. He discovered that serotonin (5-HT) and opioid peptides (endorphins) are the two main chemical substances mediating acupuncture analgesic effect. He also found that each mediator has its counterpart playing an opposite role to keep a physiologic balance. For example, nor-epinephrine in the brain works against serotonin in terms of pain control, whereas the neuropeptide known as CCK (cholecystokinin) shows an anti-opioid effect in the whole central nervous system. He was the first to find the functional balance between opioid peptides and the anti-opioid peptides (CCK and some other peptides with anti-opioid activity) that determines the efficacy of acupuncture analgesia in different individuals. These findings agree with the ancient oriental philosophy of Yin and Yang balance. In an invited article for Annual Review of Pharmacology and Toxicology, Professor Han in collaboration with professor Lars Terenius in Sweden, summarized his findings and the world advances of acupuncture research in 1982 (22:193-220).

In his attempt to find the most efficacious method for stimulation of acupuncture points, Professor Han compared the effects induced by manual twisting of the needle (manual needling), electrical stimulation via the inserted needles (electroacupuncture, EA) and electrical stimulation via skin pads placed on top of the acupoints (transcutaneous electrical acupoint stimulation), and discovered that the most important determinant of acupuncture effect is the frequency of impulses transmitted along the nerve fibers from periphery to central nervous system. Signals of different frequencies can induce the release of different kinds of chemical mediators. This led to the hypothesis of “frequency-dependent release of neuropeptides in central nervous system”. Further studies revealed that signals induced by low- and high- frequency peripheral stimulations are transmitted along different neural pathways. All these findings resulted in the design and manufacturing of a device named “Han’s acupoint nerve stimulator” (HANS), which has been used extensively for treatment of both acute and chronic pain. The main points of these discoveries have been summarized in a recent article entitled “Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies” published in the January issue of 2003 of “Trends in Neuroscience” (26:17-22).

In recent years, Professor Han has put considerable efforts on acupuncture treatment of heroin addiction using HANS as the major therapeutic measures, supplemented by a small dose of pharmacological agents when necessary. For the treatment of acute syndrome of heroin withdrawal, HANS can take care of 90% of the withdrawal symptoms. However, the most striking effect of HANS is not on the treatment of withdrawal syndrome, but to reduce or eliminate the craving for heroin. After the completion of detoxification period, a patient is discharged with a pocket sized portable device of HANS (model LY 202). A patient is instructed to perform self-treatment with the device provided whenever craving attacks. In 20 minutes the craving either disappears or dramatically diminishes, and one can continue normal life without the threat of going back to drug. The success rate of keeping drug free for more than one year without any pharmacological interventions has reached 20%, a level never attained before. These results will be presented in a chapter by Professor Han in the 4th edition of the comprehensive text book of “Substance Abuse” edited by Joyce Lowinson et al, to be published by Williams and Wilkins in 2004.

Professor Han published more than 400 scientific papers in peer-reviewed journals. His laboratory has produced a total of 56 Ph.D., 28 M.S. and 16 post-doctoral scientists, as well as more than 80 research fellows.

Professor Han is the founder and the President of the Chinese Association of the Study of Pain (CASP, China chapter of the International Association for the Study of Pain, IASP) since 1989, the founder of the Beijing Society for Neuroscience (1995), Co-founders and Deputy President of the Chinese Society for Neuroscience (1994-1999). He is the editor-in-chief of two journals, “Progress in Physiological Sciences” (1986-) and “Chinese Journal of Pain Medicine” (1995-). Six books were edited, including , the first comprehensive Neuroscience textbook in China (First edition in 1993, second edition in 1999), and in English (Vol. 1 in 1987, Vol. 2 in 1998).

Professor Han has been invited to lecture in 26 Countries and areas, and in major acupuncture congresses around the world. He was the first speaker on acupuncture mechanisms in the 1997 historical Consensus Conference on “Acupuncture” sponsored by NIH, USA.

His research activities have been supported by the National Natural Science Foundation of China (NNSFC), the Ministry of Health, and the Ministry of Science and Technology of China. He has also been the grantee of NIH, USA for the study of neurobiology of acupuncture analgesia for 12 consecutive years.

Selected Publications

Han JS, Terenius L. Neurochemical basis of acupuncture analgesia. Annual Review of Pharmacology and Toxicology. 1982; 22: 193-220
Han JS. A mesolimbic neuronal loop of analgesia. Advances in Pain Research and Therapy 1987; 10:219-243
Han JS. The role of CCK in electroacupouncture analgesia and electroacupuncture tolerance. In: Multiple CCK Receptors in CNS (Dourish CT, et al., Eds) Oxford, New York, 1992, pp 480-502
Han JS. Acupuncture activates endogenous system of analgesia. “NIH Consensus Development Conference on Acupuncture”, sponsored by Office of Alternative Medicine and Office of Medical Application of Research, Nov 3-5, 1997, NIH, Bethesda, MD, USA, pp55-60
Ulett G, Han S, Han JS. Electroacupuncture: mechanisms and clinical application. Biol Psychiatry. 1998 Jul 15;44(2):129-38.
Han JS (Ed). Principles of Neuroscience. 2nd Ed. Peking University Health Science Press, Beijing, 1999
Ren YH, Wang B, Luo F, Cui CL, Zheng JW, Han JS. Peripheral electric stimulation attenuates the expression of cocaine-induced place preference in rats. Brain Research 2002; 957: 129–135.
Han JS. Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends in Neuroscience 2003; 26:17-22
Zhang WT, Zhen J, Cui GH, Zhang KL, Zhang L, Zeng YW, Luo F, Chen CAN, Han JS. Relations between brain network activation and analgesic effect induced by low vs high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imagine study. Brain Research 2003; 982: 168-178
Fang M, Wang Y, He QH, Sun YX, Feng LB, Wang XM, Han JS. Glial cell line derived neurotrophic factors contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model. Neuroscience 2003; 117:503-512